PROGRAMME - 3rd edition of IGO MEETING

• 8.00 am     Registration & Coffee

• 8.45 am     Welcome

• 9.00 am     General Keynote lecture 
                         Jeff Bluestone (University of California - San Francisco / USA) - Immunotherapies

SESSION 1 : Solving heterogeneity in immune response
Chairpersons : Cédric Louvet & Sophie Hillion

• 09.35 am    Pierre Milpied (Centre d'Immunologie de Marseille-Luminy / France)
                         Decoding Germinal Center B cell responses at single-cell resolution

• 10.10 am     Hans Dieter Volk (Charité – University of Berlin / Germany)
                         Aged adaptive immune system on intra-tissue processes - need for distinct preclinical
                          models reflecting clinical challenges

• 10.45 am    T Cell Help Mediated by IL-2 Orchestrates BACH2 Downregulation that Allows Plasma
                         Cell Differentiation - Nicolas Hipp (UMR917, Rennes, France)

• 10.55 am     Molecular analysis of memory CD8+T cells at the single-cell level reveals a specific
                         pattern in multiple sclerosis patients Emilie Dugast (UMR1064, Nantes, France)

• 11.05 am     Coffee break and poster viewing

• 11.20 am     A molecular signature of human regulatory b cells
                         A. Grasseau (UMR1227, Brest, France)

• 11.30 am     Milena Hasan (Pasteur – Paris / France)
                          Establishing determinants of human immune variability as a path towards
                          personalized medical approaches

• 12.05 am     Leïla Périé (Institut Curie, Paris / France)
                           Heterogeneity during hematopoiesis: is the tree still a tree ?

• 12.40 pm     Lunch

SESSION 2 : Molecular based immunotherapy
Chairpersons : Aurélie Moreau & Alexis Kalergis

• 2.00 pm     Marjolein Van Egmond (VUmc / The Netherlands)
                          Antibody-Dependent Phagocytosis of Tumor Cells by Macrophages

• 2.35 pm     Eliane Piaggio (Curie Institute, Paris / France)
                        IL-2-based therapies for the treatment of autoimmunity and cancer

• 3.10 pm     Transient antibody targeting of CD45RChigh T cells to prevent the development of
                         graftversus- host disease in rats and NSG mice -
                         Laetitia Boucault (UMR1064, Nantes, France)

• 3.20 pm     Interleukin-34 contributes to regulatory T cell suppression and delays transplantation
                         rejection - Antoine Freuchet (UMR1064, Nantes, France)

• 3.30 pm     Coffee break and poster viewing

• 3.55 pm     Cancer vaccines: Designing synthetic long peptides to improve presentation of selected
                         class I and class II T cell epitopes by dendritic cells
                         Catherine Rabu (UMR1232, Nantes, France)

• 4.05 pm     Round Table: Common clinical perspectives and problems for immunotherapies.
                       J. Bluestone, H-D. Volk, P. Reinke, M. Brenner, D. Cantarovich, P. Amé, G. Blancho,
                       P. Moreau

• 4.55 pm     Sophie Lucas (UCL Louvain / Belgium)
                       Targeting GARP on Tregs: a novel approach for cancer immunotherapy ?

• 5.30 pm     Marco Frentsch (Charite – University of Berlin / Germany)
                        CD8+ T cell-derived CD40L mediates cytotoxicity against cancer cells

• 6.05pm     End of the session

• 6.10 pm     Poster session

• 7.30 pm     Gala dinner in ENSA

SESSION 3 : T Cells based immunotherapy
Chairpersons : Sylvain Simon & Béatrice Clémenceau

• 09.00 am     Malcolm K. Brenner (Bayor College of Medecine, Houston / USA)
                             Cell Therapy: Safety First

• 09.35 am     Fadi Issa (Nuffield dpt of Surgical Sciences / UK)
                          CD4+ Tregs in animal models and clinical trials of solid organ transplantation

• 10.10 am     Targeting tumor vasculature with TNF leads effector T cells to the tumor and enhances
                         therapeutic efficacy of immune checkpoint blockers in combination with adoptive cell
                         therapy - Elia Angelarita (San Raffaele, Milan, Italy)

• 10.20 am     Cyclophosphamide treatment regulates the balance of functional/exhausted
                         tumor-specific CD8+ T cells - Coralie Henin (ULB Cancer Research, Bruxelles, Belgium)

• 10.30 am     Coffee break and poster viewing

• 10.45 am     Generation of CD8+ and CD4+ regulatory T cells from human pluripotent stem cells
                         Léa Flippe (UMR1064, Nantes, France)

• 11.00 am     Chiara Bonini (Ospedale San Raffaele / Italy)
                          T memory stem cell based immunotherapy

• 11.35 am     Luis Graça (Institute of molecular medicine / Portugal)
                       Tolerance to factor VIII & Tfh regulatory cells

• 12.10 pm     Lunch

SESSION 4 : Micro-environment and resident immune cells
Chairpersons : Karin Tarte & Amédée Renand

• 1.30 pm     Matteo Bellone (Ospedale San Raffaele / Italy)
                        Microbiota and multiple myeloma

• 2.05 pm     Federica Marelli-Berg (William Harvey Research Institute / UK)
                        Modulation of immune responses through control of T cell migration

• 2.40 pm    Induction of an immunoregulatory circuit by Faecalibacterium prausnitzii via Ahr:
                         potential implications in colorectal cancer
                         Emmanuelle Godefroy (UMR1232, Nantes, France)

• 2.50 pm    Interleukin-22-binding protein (IL-22BP) regulates IL-22 functions during gut
                         homeostasis - Ahmed Abidi (UMR1064, Nantes, France)

• 3.00 pm    Coffee break and poster viewing

• 3.15 pm   Human tolerogenic dendritic cells regulate immune response through lactate synthesis
                         and regulatory T cell induction - Eros Marin (UMR1064, Nantes, France)

• 3.25 pm     Jean-Luc Teillaud (Centre de Recherche des Cordeliers / France)
                       A new comer in the arsenal of lung cancer patients : B cells in tertiary lymphoids
                         structures

• 4.00 pm    General Keynote lecture – Oren Parnas (Hebrew University of Jerusalem / Israël)
                      Dissecting Regulatory Networks That Mediate Dendritic Cell Suppression

• 4.35 pm    Awards and conclusion of the meeting (Nathalie Labarrière, Deputy Director Labex IGO)