
PROGRAMME - 3rd edition of IGO MEETING
Tuesday 17th April 2018 - Morning
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8.00 am Registration & Coffee
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8.45 am Welcome
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9.00 am General Keynote lecture
Jeff Bluestone (University of California - San Francisco / USA) - Immunotherapies
SESSION 1 : Solving heterogeneity in immune response
Chairpersons : Cédric Louvet & Sophie Hillion
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09.35 am Pierre Milpied (Centre d'Immunologie de Marseille-Luminy / France)
Decoding Germinal Center B cell responses at single-cell resolution -
10.10 am Hans Dieter Volk (Charité – University of Berlin / Germany)
Aged adaptive immune system on intra-tissue processes - need for distinct preclinical
models reflecting clinical challenges -
10.45 am T Cell Help Mediated by IL-2 Orchestrates BACH2 Downregulation that Allows Plasma
Cell Differentiation - Nicolas Hipp (UMR917, Rennes, France) -
10.55 am Molecular analysis of memory CD8+T cells at the single-cell level reveals a specific
pattern in multiple sclerosis patients Emilie Dugast (UMR1064, Nantes, France) -
11.05 am Coffee break and poster viewing
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11.20 am A molecular signature of human regulatory b cells
A. Grasseau (UMR1227, Brest, France) -
11.30 am Milena Hasan (Pasteur – Paris / France)
Establishing determinants of human immune variability as a path towards
personalized medical approaches -
12.05 am Leïla Périé (Institut Curie, Paris / France)
Heterogeneity during hematopoiesis: is the tree still a tree ? -
12.40 pm Lunch
Tuesday 17th April 2018 - Afternoon
SESSION 2 : Molecular based immunotherapy
Chairpersons : Aurélie Moreau & Alexis Kalergis
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2.00 pm Marjolein Van Egmond (VUmc / The Netherlands)
Antibody-Dependent Phagocytosis of Tumor Cells by Macrophages -
2.35 pm Eliane Piaggio (Curie Institute, Paris / France)
IL-2-based therapies for the treatment of autoimmunity and cancer -
3.10 pm Transient antibody targeting of CD45RChigh T cells to prevent the development of
graftversus- host disease in rats and NSG mice -
Laetitia Boucault (UMR1064, Nantes, France) -
3.20 pm Interleukin-34 contributes to regulatory T cell suppression and delays transplantation
rejection - Antoine Freuchet (UMR1064, Nantes, France) -
3.30 pm Coffee break and poster viewing
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3.55 pm Cancer vaccines: Designing synthetic long peptides to improve presentation of selected
class I and class II T cell epitopes by dendritic cells
Catherine Rabu (UMR1232, Nantes, France) -
4.05 pm Round Table: Common clinical perspectives and problems for immunotherapies.
J. Bluestone, H-D. Volk, P. Reinke, M. Brenner, D. Cantarovich, P. Amé, G. Blancho,
P. Moreau -
4.55 pm Sophie Lucas (UCL Louvain / Belgium)
Targeting GARP on Tregs: a novel approach for cancer immunotherapy ? -
5.30 pm Marco Frentsch (Charite – University of Berlin / Germany)
CD8+ T cell-derived CD40L mediates cytotoxicity against cancer cells -
6.05pm End of the session
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6.10 pm Poster session
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7.30 pm Gala dinner in ENSA
Wednesday 18th April 2018 - Morning
SESSION 3 : T Cells based immunotherapy
Chairpersons : Sylvain Simon & Béatrice Clémenceau
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09.00 am Malcolm K. Brenner (Bayor College of Medecine, Houston / USA)
Cell Therapy: Safety First -
09.35 am Fadi Issa (Nuffield dpt of Surgical Sciences / UK)
CD4+ Tregs in animal models and clinical trials of solid organ transplantation -
10.10 am Targeting tumor vasculature with TNF leads effector T cells to the tumor and enhances
therapeutic efficacy of immune checkpoint blockers in combination with adoptive cell
therapy - Elia Angelarita (San Raffaele, Milan, Italy) -
10.20 am Cyclophosphamide treatment regulates the balance of functional/exhausted
tumor-specific CD8+ T cells - Coralie Henin (ULB Cancer Research, Bruxelles, Belgium) -
10.30 am Coffee break and poster viewing
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10.45 am Generation of CD8+ and CD4+ regulatory T cells from human pluripotent stem cells
Léa Flippe (UMR1064, Nantes, France) -
11.00 am Chiara Bonini (Ospedale San Raffaele / Italy)
T memory stem cell based immunotherapy -
11.35 am Luis Graça (Institute of molecular medicine / Portugal)
Tolerance to factor VIII & Tfh regulatory cells -
12.10 pm Lunch
Wednesday 18th April 2018 - Afternoon
SESSION 4 : Micro-environment and resident immune cells
Chairpersons : Karin Tarte & Amédée Renand
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1.30 pm Matteo Bellone (Ospedale San Raffaele / Italy)
Microbiota and multiple myeloma -
2.05 pm Federica Marelli-Berg (William Harvey Research Institute / UK)
Modulation of immune responses through control of T cell migration -
2.40 pm Induction of an immunoregulatory circuit by Faecalibacterium prausnitzii via Ahr:
potential implications in colorectal cancer
Emmanuelle Godefroy (UMR1232, Nantes, France) -
2.50 pm Interleukin-22-binding protein (IL-22BP) regulates IL-22 functions during gut
homeostasis - Ahmed Abidi (UMR1064, Nantes, France) -
3.00 pm Coffee break and poster viewing
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3.15 pm Human tolerogenic dendritic cells regulate immune response through lactate synthesis
and regulatory T cell induction - Eros Marin (UMR1064, Nantes, France) -
3.25 pm Jean-Luc Teillaud (Centre de Recherche des Cordeliers / France)
A new comer in the arsenal of lung cancer patients : B cells in tertiary lymphoids
structures -
4.00 pm General Keynote lecture – Oren Parnas (Hebrew University of Jerusalem / Israël)
Dissecting Regulatory Networks That Mediate Dendritic Cell Suppression -
4.35 pm Awards and conclusion of the meeting (Nathalie Labarrière, Deputy Director Labex IGO)
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Mis à jour le 11 April 2018 par Valérie PECQUERET.