Journal of Immunology

IL-26 Confers Proinflammatory Properties to Extracellular DNA

Poli C, Augusto JF, Dauvé J, Adam C, Preisser L, Larochette V, Pignon P, Savina A, Blanchard S, Subra JF, Chevailler A, Procaccio V, Croué A, Créminon C, Morel A, Delneste Y, Fickenscher H, Jeannin P

J Immunol. 2017 May 1;198(9):3650-3661 - Download full text


Butyrophilin 3A (BTN3A, CD277)-specific antibody 20.1 differentially activates Vγ9Vδ2 TCR clonotypes and interferes with phosphoantigen activation

Starick L, Riano F, Karunakaran MM, Kunzmann V, Li J, Kreiss M, Amslinger S, Scotet E, Olive D, De Libero G, Herrmann T

Eur J Immunol. 2017 Jun;47(6):982-992 - Download full text


Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells

Delaunay T, Violland M, Boisgerault N, Dutoit S, Vignard V, Münz C, Gannage M, Dréno B, Vaivode K, Pjanova D, Labarrière N, Wang Y, Chiocca EA, Boeuf FL, Bell JC, Erbs P, Tangy F, Grégoire M, Fonteneau JF

Oncoimmunology. 2017 Dec 26;7(3):e1407897

clinical epig

Combining cytogenetic and epigenetic approaches in chronic lymphocytic leukemia improves prognosis prediction for patients with isolated 13q deletion

Bagacean C, Le Dantec C, Berthou C, Tempescul A, Saad H, Bordron A, Zdrenghea M, Cristea V, Douet-Guilbert N, Renaudineau Y

Clin Epigenetics. 2017 Nov 28;9:122 - Download full text

Clinical Immuno

Influence of drug molecules on regulatory B cells

Amrouche K, Jamin C

Clin Immunol. 2017 Nov;184:1-10 - Download full text


Immunophenotyping As a New Tool for Classification and Monitoring of Systemic Autoimmune Diseases

Renaudineau Y

Clin Rev Allergy Immunol. 2017 Oct;53(2):177-180


Memory B Cells and Response to Abatacept in Rheumatoid Arthritis

Gazeau P, Alegria GC, Devauchelle-Pensec V, Jamin C, Lemerle J, Bendaoud B, Brooks WH, Saraux A, Cornec D, Renaudineau Y

Clin Rev Allergy Immunol. 2017 Oct;53(2):166-176

Clinical Immuno

Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study

Duffy D, Rouilly V, Braudeau C, Corbière V, Djebali R, Ungeheuer MN, Josien R, LaBrie ST, Lantz O, Louis D, Martinez-Caceres E, Mascart F, Ruiz de Morales JG, Ottone C, Redjah L, Guen NS, Savenay A, Schmolz M, Toubert A, Albert ML; Multinational FOCIS Centers of Excellence

Clin Immunol. 2017 Oct;183:325-335 - Download full text


PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy?

Simon S, Labarriere N

Oncoimmunology. 2017 Sep 14;7(1):e1364828 - Download full text

Clinical Cancer

Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity

Oizel K, Chauvin C, Oliver L, Gratas C, Geraldo F, Jarry U, Scotet E, Rabe M, Alves-Guerra MC, Teusan R, Gautier F, Loussouarn D, Compan V, Martinou JC, Vallette FM, Pecqueur C

Clin Cancer Res. 2017 Oct 15;23(20):6292-6304 - Download full text

Arthritis Care

Severe Health-Related Quality of Life Impairment in Active Primary Sjögren's Syndrome and Patient-Reported Outcomes: Data From a Large Therapeutic Trial

Cornec D, Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, Berthelot JM, Perdriger A, Puéchal X, Le Guern V, Sibilia J, Gottenberg JE, Chiche L, Hachulla E, Yves Hatron P, Goeb V, Hayem G, Morel J, Zarnitsky C, Dubost JJ, Saliou P, Pers JO, Seror R, Saraux A

Arthritis Care Res (Hoboken). 2017 Apr;69(4):528-535 - Download full text

Ann Rheum

Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjögren's syndrome

Charras A, Konsta OD, Le Dantec C, Bagacean C, Kapsogeorgou EK, Tzioufas AG, Pers JO, Bordron A, Renaudineau Y

Ann Rheum Dis. 2017 Mar;76(3):625-628

revue medecine interne

Influence of epigenetic in Sjögren's syndrome

Bordron A, Charras A, Le Dantec C, Renaudineau Y

Rev Med Interne. 2018 May;39(5):346-351 - Download full text


Alterations in DNA methylation/demethylation intermediates predict clinical outcome in chronic lymphocytic leukemia

Bagacean C, Tempescul A, Le Dantec C, Bordron A, Mohr A, Saad H, Olivier V, Zdrenghea M, Cristea V, Cartron PF, Douet-Guilbert N, Berthou C, Renaudineau Y

Oncotarget. 2017 Aug 9;8(39):65699-65716 - Download full text

Journal Hepat

Alloantigen gene transfer to hepatocytes promotes tolerance to pancreatic islet graft by inducing CD8+ regulatory T cells

Le Guen V, Judor JP, Boeffard F, Gauttier V, Ferry N, Soulillou JP, Brouard S, Conchon S

J Hepatol. 2017 Apr;66(4):765-777 - Download full text


In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Bézie S, Usal C, Guillonneau C

J Vis Exp. 2017 Aug 12;(126)

Journal of allergy

Human regulatory B cells control the TFH cell response

Achour A, Simon Q, Mohr A, Séité JF, Youinou P, Bendaoud B, Ghedira I, Pers JO, Jamin C

J Allergy Clin Immunol. 2017 Jul;140(1):215-222 - Download full text

Frontiers in immunology

IL-15 Harnesses Pro-inflammatory Function of TEMRA CD8 in Kidney-Transplant Recipients

Tilly G, Doan-Ngoc TM, Yap M, Caristan A, Jacquemont L, Danger R, Cadoux M, Bruneau S, Giral M, Guerif P, Nicol B, Garcia A, Laplaud DA, Brouard S, Pecqueur Hellman C, Degauque N

Front Immunol. 2017 Jun 30;8:778 - Download full text

Kidney International

A composite score associated with spontaneous operational tolerance in kidney transplant recipients

Danger R, Chesneau M, Paul C, Guérif P, Durand M, Newell KA, Kanaparthi S, Turka LA, Soulillou JP, Houlgatte R, Giral M, Ramstein G, Brouard S

Kidney Int. 2017 Jun;91(6):1473-1481



21st Nantes Actualités Transplantation: "When Stem Cells Meet Immunology"

Anegon I, Nguyen TH

Transplantation. 2017 Jan;101(1):12-16



Improved Analyses of CD8+ T Cell Specificities Using Multimers of Peptide MHC Complexes Coupled to DNA Barcodes

Guillonneau C, David L, Anegon I.

Transplantation. 2017 Feb;101(2):219-221


jci cover

Transient antibody targeting of CD45RC induces transplant tolerance and potent antigen-specific regulatory T cells

Picarda E, Bézie S, Boucault L, Autrusseau E, Kilens S, Meistermann D, Martinet B, Daguin V, Donnart A, Charpentier E, David L, Anegon I, Guillonneau C

JCI Insight. 2017 Feb 9;2(3):e90088 - Download full text


Cancer Research

Emergence of High-Avidity Melan-A–Specific Clonotypes as a Reflection of Anti–PD-1 Clinical Efficacy

Sylvain Simon, Virginie Vignard, Emilie Varey, Tiphaine Parrot,Anne-Chantal Knol1,Amir Khammari, Nadine Gervois, Francois Lang,Brigitte Dreno and Nathalie Labarriere

Cancer Research, Dec 2017 - Download full text


Current Gene Therapy
Modulation of the Type I Interferon Response Defines the Sensitivity of Human Melanoma Cells to Oncolytic Measles Virus

Ferdaous Allagui, Carole Achard, Clarisse Panterne, Chantal Combredet, Nathalie Labarrière,Brigitte Dréno, Amel Benammar Elgaaied, Daniel Pouliquen, Frédéric Tangy, Jean-François Fonteneau, Marc Grégoire and Nicolas Boisgerault

Curr Gene Ther. 2017;16(6):419-428

Frontiers in immunology

Broad Impairment of Natural Killer Cells from Operationally Tolerant Kidney Transplanted Patients

Emilie Dugast, Gaëlle David, Romain Oger, Richard Danger, Jean-Paul Judor, Katia Gagne, Mélanie Chesneau, Nicolas Degauque,Pascale Paul, Christophe Picard, Pierrick Guérif, Sophie Conchon, Magali Giral, Nadine Gervois, Christelle Retière, Sophie Brouard

Front. Immunol., December 2017 | Volume 8 | Article 1721  - Download full text

Thymic stromal lymphopoietin does not activate human basophils

Nina Salabert-Le Guen, PhD, Caroline Hémont, PharmD, PhD, Agathe Delbove,MD, Caroline Poli, MD, PhD, Cécile Braudeau, PhD, Aurélie Fantou, PharmD, Karine Amouriaux, PhD, Gaelle Bériou, PhD, Jérôme C. Martin, PharmD, PhD, Luc Colas,MD, Vassili Soumelis, MD, PhD, Régis Josien, MD, PhD

Journal of Allergy and Clinical Immunology (Dec 2017) - Download full text

Scientific report Nature
Generation of gene-edited rats by delivery of CRISPR/Cas9 protein and donor DNA into intact zygotes using electroporation

S. Rémy, V. Chenouard, L. Tesson, C. Usal, S. Ménoret, L. Brusselle, J.-M. Heslan, T. H. Nguyen, J. Bellien, J. Mérot, A. De Cian,C. Giovannangeli, J.-P. Concordet & I. Anegon

Scientific Reports 7, Article number: 16554 (2017) - Download full text

Nature Comm
IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression

N. Hipp, H.Symington, C. Pastoret, G. Caron, C. Monvoisin, K.Tarte, T. Fest & C. Delaloy

Nature Communications 8, Article number: 1443 (2017) - Download full text

Frontiers in immunology

Impact of chronic viral infection on T-cell dependent humoral immune response

Stephane Rodriguez, Mikaël Roussel, Karin Tarte, Patricia Ame-Thomas

Front. Immunol., 31 October 2017  - Download full text


Frontiers in immunology

Pro-inflammatory state in Monoclonal gammopathy of Undetermined significance and in Multiple Myeloma is characterized by low sialylation of Pathogenspecific and Other Monoclonal immunoglobulins

A. Bosseboeuf, S. Allain-Maillet, N. Mennesson, A. Tallet,Cédric Rossi, L. Garderet, D. Caillot, P. Moreau, E. Piver, F. Girodon, H. Perreault, S. Brouard, A. Nicot, E. Bigot-Corbel, S. Hermouet and J. Harb

Front Immunol. 2017 Oct 19;8:1347 - Download full text

Transgenic research
Advances in transgenic animal models and techniques

S. Ménoret , L. Tesson, S. Rémy, C. Usal, L.-H. Ouisse, L. Brusselle, V. Chenouard, I. Anegon

Transgenic Res (2017) 26:703–708 - Download full text

Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses

Maria Dolores Lopez Robles, Annaick Pallier, Virginie Huchet, Laetitia Le Texier, Severine Remy, Cecile Braudeau, Laurence Delbos, Aurelie Moreau, Cedric Louvet, Carole Brosseau, Pierre-Joseph Royer, Antoine Magnan, Franck Halary, Regis Josien, Maria-Cristina Cuturi, Ignacio Anegon and Elise Chiffoleau

Blood Advances (2017) 1:557-568 - Download full text

Frontiers in immunology
Heme-Oxygenase-1 Expression Contributes to the Immunoregulation Induced by Fasciola hepatica and Promotes Infection

Carasi P, Rodríguez E, da Costa V, Frigerio S, Brossard N, Noya V, Robello C,Anegón I, Freire T

Frontiers in immunology 2017, Jul 26;8:883 - Download full text

Cellular and molecular life
Immunoregulatory properties of the cytokine Il-34

C. Guillonneau, S. Bézie, I. Anegon

Cellular and Molecular Life Sciences, 2017,  Jul;74(14):2569-2586 - Download full text

Inhibition of effector antigen-specific T cells by intradermal administration of heme-oxygenase-1 inducers

T. Simon, J. Pogu, S. Rémy, F. Brau, S. Pogu, M. Maquigneau, J.-F. Fonteneau, B. Vanhove, G. Blancho, E. Piaggio, I. Anegon & P. Blancou

J Autoimmunity, 2017 Jul;81:44-55 - Download full text

Journal of Immunology
The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells

Peigné CM, Léger A, Gesnel MC, Konczak F, Olive D, Bonneville M, Breathnach R, Scotet E

J Immunol. 2017 Jun 1;198(11):4228-4234 - Download full text

Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells

Chen HC, Joalland N, Bridgeman JS, Alchami FS, Jarry U, Khan MWA, Piggott L, Shanneik Y, Li J, Herold MJ, Herrmann T, Price DA, Gallimore AM, Clarkson RW, Scotet E, Moser B, Eberl M

Immunol Cell Biol. 2017 Aug;95(7):620-629 - Download full text

Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminative human monoclonal antibodies

Ouisse LH, Gautreau-Rolland L, Devilder MC, Osborn M, Moyon M, Visentin J, Halary F, Bruggemann M, Buelow R, Anegon I, Saulquin X

BMC Biotechnol. 2017 Jan 9;17(1):3 - Download full text

Value of biomarkers for predicting immunoglobulin A vasculitis nephritis outcome in an adult prospective cohort

Berthelot L, Jamin A, Viglietti D, Chemouny JM, Ayari H, Pierre M, Housset P, Sauvaget V, Hurtado-Nedelec M, Vrtovsnik F, Daugas E; HSPrognosis Group, Monteiro RC, Pillebout E

Nephrol Dial Transplant. 2017 Nov 3

Journal of Immunology
Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation

Martin JC, Wolk K, Bériou G, Abidi A, Witte-Händel E, Louvet C, Kokolakis G, Drujont L, Dumoutier L, Renauld JC, Sabat R, Josien R

J Immunol. 2017 May 1;198(9):3671-3678 - Download full text

Pathogenic Variants in Complement Genes and Risk of Atypical Hemolytic Uremic Syndrome Relapse after Eculizumab Discontinuation

Fakhouri F, Fila M, Provôt F, Delmas Y, Barbet C, Châtelet V, Rafat C, Cailliez M, Hogan J, Servais A, Karras A, Makdassi R, Louillet F, Coindre JP, Rondeau E, Loirat C, Frémeaux-Bacchi V

Clin J Am Soc Nephrol. 2017 Jan 6;12(1):50-59 - Download full text

Frontiers in immunology
CD28 Blockade Ex Vivo Induces Alloantigen-Specific Immune Tolerance but Preserves T-Cell Pathogen Reactivity

Dillinger B, Ahmadi-Erber S, Soukup K, Halfmann A, Schrom S, Vanhove B, Steinberger P, Geyeregger R, Ladisch S, Dohnal AM

Front Immunol. 2017 Sep 20;8:1152 - Download full text

Clin rev allergy
Lymphocyte Disturbances in Primary Antiphospholipid Syndrome and Application to Venous Thromboembolism Follow-Up

Simonin L, Pasquier E, Leroyer C, Cornec D, Lemerle J, Bendaoud B, Hillion S, Pers JO, Couturaud F, Renaudineau Y

Clin Rev Allergy Immunol. 2017 Aug;53(1):14-27

Blood biomarkers of kidney transplant rejection, an endless search

Lola Jacquemont, Jean-Paul Soulillou and Nicolas Degauque

Exp. Review of Molecular Diagn, Volume 17, 2017 - Issue 7 -

Frontiers in immunology
Dysregulated responsiveness of circulating dendritic cells to Toll-like receptors in ANCA-associated vasculitis

C. Braudeau, A. Neel, K. Amouriaux, JC Martin, M. Rimbert, A. Besançon, S. Giraudet, C. Terrien, M. Aliaga, N. Salabert-Le Guen, C. Hémont, M. Hamidou, R. Josien

Front Immunol. 2017; 8: 102.  - Download full text