
LABEX PUBLICATIONS 2017
IL-26 Confers Proinflammatory Properties to Extracellular DNA
Poli C, Augusto JF, Dauvé J, Adam C, Preisser L, Larochette V, Pignon P, Savina A, Blanchard S, Subra JF, Chevailler A, Procaccio V, Croué A, Créminon C, Morel A, Delneste Y, Fickenscher H, Jeannin P
J Immunol. 2017 May 1;198(9):3650-3661 - Download full text
Butyrophilin 3A (BTN3A, CD277)-specific antibody 20.1 differentially activates Vγ9Vδ2 TCR clonotypes and interferes with phosphoantigen activation
Starick L, Riano F, Karunakaran MM, Kunzmann V, Li J, Kreiss M, Amslinger S, Scotet E, Olive D, De Libero G, Herrmann T
Eur J Immunol. 2017 Jun;47(6):982-992 - Download full text
Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells
Delaunay T, Violland M, Boisgerault N, Dutoit S, Vignard V, Münz C, Gannage M, Dréno B, Vaivode K, Pjanova D, Labarrière N, Wang Y, Chiocca EA, Boeuf FL, Bell JC, Erbs P, Tangy F, Grégoire M, Fonteneau JF
Oncoimmunology. 2017 Dec 26;7(3):e1407897
Combining cytogenetic and epigenetic approaches in chronic lymphocytic leukemia improves prognosis prediction for patients with isolated 13q deletion
Bagacean C, Le Dantec C, Berthou C, Tempescul A, Saad H, Bordron A, Zdrenghea M, Cristea V, Douet-Guilbert N, Renaudineau Y
Clin Epigenetics. 2017 Nov 28;9:122 - Download full text
Influence of drug molecules on regulatory B cells
Amrouche K, Jamin C
Clin Immunol. 2017 Nov;184:1-10 - Download full text
Immunophenotyping As a New Tool for Classification and Monitoring of Systemic Autoimmune Diseases
Renaudineau Y
Clin Rev Allergy Immunol. 2017 Oct;53(2):177-180
Memory B Cells and Response to Abatacept in Rheumatoid Arthritis
Gazeau P, Alegria GC, Devauchelle-Pensec V, Jamin C, Lemerle J, Bendaoud B, Brooks WH, Saraux A, Cornec D, Renaudineau Y
Clin Rev Allergy Immunol. 2017 Oct;53(2):166-176
Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study
Duffy D, Rouilly V, Braudeau C, Corbière V, Djebali R, Ungeheuer MN, Josien R, LaBrie ST, Lantz O, Louis D, Martinez-Caceres E, Mascart F, Ruiz de Morales JG, Ottone C, Redjah L, Guen NS, Savenay A, Schmolz M, Toubert A, Albert ML; Multinational FOCIS Centers of Excellence
Clin Immunol. 2017 Oct;183:325-335 - Download full text
PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy?
Simon S, Labarriere N
Oncoimmunology. 2017 Sep 14;7(1):e1364828 - Download full text
Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity
Oizel K, Chauvin C, Oliver L, Gratas C, Geraldo F, Jarry U, Scotet E, Rabe M, Alves-Guerra MC, Teusan R, Gautier F, Loussouarn D, Compan V, Martinou JC, Vallette FM, Pecqueur C
Clin Cancer Res. 2017 Oct 15;23(20):6292-6304 - Download full text
Severe Health-Related Quality of Life Impairment in Active Primary Sjögren's Syndrome and Patient-Reported Outcomes: Data From a Large Therapeutic Trial
Cornec D, Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, Berthelot JM, Perdriger A, Puéchal X, Le Guern V, Sibilia J, Gottenberg JE, Chiche L, Hachulla E, Yves Hatron P, Goeb V, Hayem G, Morel J, Zarnitsky C, Dubost JJ, Saliou P, Pers JO, Seror R, Saraux A
Arthritis Care Res (Hoboken). 2017 Apr;69(4):528-535 - Download full text
Cell-specific epigenome-wide DNA methylation profile in long-term cultured minor salivary gland epithelial cells from patients with Sjögren's syndrome
Charras A, Konsta OD, Le Dantec C, Bagacean C, Kapsogeorgou EK, Tzioufas AG, Pers JO, Bordron A, Renaudineau Y
Ann Rheum Dis. 2017 Mar;76(3):625-628
Influence of epigenetic in Sjögren's syndrome
Bordron A, Charras A, Le Dantec C, Renaudineau Y
Rev Med Interne. 2018 May;39(5):346-351 - Download full text
Alterations in DNA methylation/demethylation intermediates predict clinical outcome in chronic lymphocytic leukemia
Bagacean C, Tempescul A, Le Dantec C, Bordron A, Mohr A, Saad H, Olivier V, Zdrenghea M, Cristea V, Cartron PF, Douet-Guilbert N, Berthou C, Renaudineau Y
Oncotarget. 2017 Aug 9;8(39):65699-65716 - Download full text
Alloantigen gene transfer to hepatocytes promotes tolerance to pancreatic islet graft by inducing CD8+ regulatory T cells
Le Guen V, Judor JP, Boeffard F, Gauttier V, Ferry N, Soulillou JP, Brouard S, Conchon S
J Hepatol. 2017 Apr;66(4):765-777 - Download full text
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Bézie S, Usal C, Guillonneau C
J Vis Exp. 2017 Aug 12;(126)
Human regulatory B cells control the TFH cell response
Achour A, Simon Q, Mohr A, Séité JF, Youinou P, Bendaoud B, Ghedira I, Pers JO, Jamin C
J Allergy Clin Immunol. 2017 Jul;140(1):215-222 - Download full text
IL-15 Harnesses Pro-inflammatory Function of TEMRA CD8 in Kidney-Transplant Recipients
Tilly G, Doan-Ngoc TM, Yap M, Caristan A, Jacquemont L, Danger R, Cadoux M, Bruneau S, Giral M, Guerif P, Nicol B, Garcia A, Laplaud DA, Brouard S, Pecqueur Hellman C, Degauque N
Front Immunol. 2017 Jun 30;8:778 - Download full text
A composite score associated with spontaneous operational tolerance in kidney transplant recipients
Danger R, Chesneau M, Paul C, Guérif P, Durand M, Newell KA, Kanaparthi S, Turka LA, Soulillou JP, Houlgatte R, Giral M, Ramstein G, Brouard S
Kidney Int. 2017 Jun;91(6):1473-1481
21st Nantes Actualités Transplantation: "When Stem Cells Meet Immunology"
Anegon I, Nguyen TH
Transplantation. 2017 Jan;101(1):12-16
Improved Analyses of CD8+ T Cell Specificities Using Multimers of Peptide MHC Complexes Coupled to DNA Barcodes
Guillonneau C, David L, Anegon I.
Transplantation. 2017 Feb;101(2):219-221
Transient antibody targeting of CD45RC induces transplant tolerance and potent antigen-specific regulatory T cells
Picarda E, Bézie S, Boucault L, Autrusseau E, Kilens S, Meistermann D, Martinet B, Daguin V, Donnart A, Charpentier E, David L, Anegon I, Guillonneau C
JCI Insight. 2017 Feb 9;2(3):e90088 - Download full text
Emergence of High-Avidity Melan-A–Specific Clonotypes as a Reflection of Anti–PD-1 Clinical Efficacy
Sylvain Simon, Virginie Vignard, Emilie Varey, Tiphaine Parrot,Anne-Chantal Knol1,Amir Khammari, Nadine Gervois, Francois Lang,Brigitte Dreno and Nathalie Labarriere
Cancer Research, Dec 2017 - Download full text
Modulation of the Type I Interferon Response Defines the Sensitivity of Human Melanoma Cells to Oncolytic Measles Virus
Ferdaous Allagui, Carole Achard, Clarisse Panterne, Chantal Combredet, Nathalie Labarrière,Brigitte Dréno, Amel Benammar Elgaaied, Daniel Pouliquen, Frédéric Tangy, Jean-François Fonteneau, Marc Grégoire and Nicolas Boisgerault
Curr Gene Ther. 2017;16(6):419-428
Broad Impairment of Natural Killer Cells from Operationally Tolerant Kidney Transplanted Patients
Emilie Dugast, Gaëlle David, Romain Oger, Richard Danger, Jean-Paul Judor, Katia Gagne, Mélanie Chesneau, Nicolas Degauque,Pascale Paul, Christophe Picard, Pierrick Guérif, Sophie Conchon, Magali Giral, Nadine Gervois, Christelle Retière, Sophie Brouard
Front. Immunol., December 2017 | Volume 8 | Article 1721 - Download full text
Thymic stromal lymphopoietin does not activate human basophils
Nina Salabert-Le Guen, PhD, Caroline Hémont, PharmD, PhD, Agathe Delbove,MD, Caroline Poli, MD, PhD, Cécile Braudeau, PhD, Aurélie Fantou, PharmD, Karine Amouriaux, PhD, Gaelle Bériou, PhD, Jérôme C. Martin, PharmD, PhD, Luc Colas,MD, Vassili Soumelis, MD, PhD, Régis Josien, MD, PhD
Journal of Allergy and Clinical Immunology (Dec 2017) - Download full text
Generation of gene-edited rats by delivery of CRISPR/Cas9 protein and donor DNA into intact zygotes using electroporation
S. Rémy, V. Chenouard, L. Tesson, C. Usal, S. Ménoret, L. Brusselle, J.-M. Heslan, T. H. Nguyen, J. Bellien, J. Mérot, A. De Cian,C. Giovannangeli, J.-P. Concordet & I. Anegon
Scientific Reports 7, Article number: 16554 (2017) - Download full text
IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression
N. Hipp, H.Symington, C. Pastoret, G. Caron, C. Monvoisin, K.Tarte, T. Fest & C. Delaloy
Nature Communications 8, Article number: 1443 (2017) - Download full text
Impact of chronic viral infection on T-cell dependent humoral immune response
Stephane Rodriguez, Mikaël Roussel, Karin Tarte, Patricia Ame-Thomas
Front. Immunol., 31 October 2017 - Download full text
Pro-inflammatory state in Monoclonal gammopathy of Undetermined significance and in Multiple Myeloma is characterized by low sialylation of Pathogenspecific and Other Monoclonal immunoglobulins
A. Bosseboeuf, S. Allain-Maillet, N. Mennesson, A. Tallet,Cédric Rossi, L. Garderet, D. Caillot, P. Moreau, E. Piver, F. Girodon, H. Perreault, S. Brouard, A. Nicot, E. Bigot-Corbel, S. Hermouet and J. Harb
Front Immunol. 2017 Oct 19;8:1347 - Download full text
Advances in transgenic animal models and techniques
S. Ménoret , L. Tesson, S. Rémy, C. Usal, L.-H. Ouisse, L. Brusselle, V. Chenouard, I. Anegon
Transgenic Res (2017) 26:703–708 - Download full text
Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses
Maria Dolores Lopez Robles, Annaick Pallier, Virginie Huchet, Laetitia Le Texier, Severine Remy, Cecile Braudeau, Laurence Delbos, Aurelie Moreau, Cedric Louvet, Carole Brosseau, Pierre-Joseph Royer, Antoine Magnan, Franck Halary, Regis Josien, Maria-Cristina Cuturi, Ignacio Anegon and Elise Chiffoleau
Blood Advances (2017) 1:557-568 - Download full text
Heme-Oxygenase-1 Expression Contributes to the Immunoregulation Induced by Fasciola hepatica and Promotes Infection
Carasi P, Rodríguez E, da Costa V, Frigerio S, Brossard N, Noya V, Robello C,Anegón I, Freire T
Frontiers in immunology 2017, Jul 26;8:883 - Download full text
Immunoregulatory properties of the cytokine Il-34
C. Guillonneau, S. Bézie, I. Anegon
Cellular and Molecular Life Sciences, 2017, Jul;74(14):2569-2586 - Download full text
Inhibition of effector antigen-specific T cells by intradermal administration of heme-oxygenase-1 inducers
T. Simon, J. Pogu, S. Rémy, F. Brau, S. Pogu, M. Maquigneau, J.-F. Fonteneau, B. Vanhove, G. Blancho, E. Piaggio, I. Anegon & P. Blancou
J Autoimmunity, 2017 Jul;81:44-55 - Download full text
The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells
Peigné CM, Léger A, Gesnel MC, Konczak F, Olive D, Bonneville M, Breathnach R, Scotet E
J Immunol. 2017 Jun 1;198(11):4228-4234 - Download full text
Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells
Chen HC, Joalland N, Bridgeman JS, Alchami FS, Jarry U, Khan MWA, Piggott L, Shanneik Y, Li J, Herold MJ, Herrmann T, Price DA, Gallimore AM, Clarkson RW, Scotet E, Moser B, Eberl M
Immunol Cell Biol. 2017 Aug;95(7):620-629 - Download full text
Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminative human monoclonal antibodies
Ouisse LH, Gautreau-Rolland L, Devilder MC, Osborn M, Moyon M, Visentin J, Halary F, Bruggemann M, Buelow R, Anegon I, Saulquin X
BMC Biotechnol. 2017 Jan 9;17(1):3 - Download full text
Value of biomarkers for predicting immunoglobulin A vasculitis nephritis outcome in an adult prospective cohort
Berthelot L, Jamin A, Viglietti D, Chemouny JM, Ayari H, Pierre M, Housset P, Sauvaget V, Hurtado-Nedelec M, Vrtovsnik F, Daugas E; HSPrognosis Group, Monteiro RC, Pillebout E
Nephrol Dial Transplant. 2017 Nov 3
Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation
Martin JC, Wolk K, Bériou G, Abidi A, Witte-Händel E, Louvet C, Kokolakis G, Drujont L, Dumoutier L, Renauld JC, Sabat R, Josien R
J Immunol. 2017 May 1;198(9):3671-3678 - Download full text
Pathogenic Variants in Complement Genes and Risk of Atypical Hemolytic Uremic Syndrome Relapse after Eculizumab Discontinuation
Fakhouri F, Fila M, Provôt F, Delmas Y, Barbet C, Châtelet V, Rafat C, Cailliez M, Hogan J, Servais A, Karras A, Makdassi R, Louillet F, Coindre JP, Rondeau E, Loirat C, Frémeaux-Bacchi V
Clin J Am Soc Nephrol. 2017 Jan 6;12(1):50-59 - Download full text
CD28 Blockade Ex Vivo Induces Alloantigen-Specific Immune Tolerance but Preserves T-Cell Pathogen Reactivity
Dillinger B, Ahmadi-Erber S, Soukup K, Halfmann A, Schrom S, Vanhove B, Steinberger P, Geyeregger R, Ladisch S, Dohnal AM
Front Immunol. 2017 Sep 20;8:1152 - Download full text
Lymphocyte Disturbances in Primary Antiphospholipid Syndrome and Application to Venous Thromboembolism Follow-Up
Simonin L, Pasquier E, Leroyer C, Cornec D, Lemerle J, Bendaoud B, Hillion S, Pers JO, Couturaud F, Renaudineau Y
Clin Rev Allergy Immunol. 2017 Aug;53(1):14-27
Blood biomarkers of kidney transplant rejection, an endless search
Lola Jacquemont, Jean-Paul Soulillou and Nicolas Degauque
Exp. Review of Molecular Diagn, Volume 17, 2017 - Issue 7 -
Dysregulated responsiveness of circulating dendritic cells to Toll-like receptors in ANCA-associated vasculitis
C. Braudeau, A. Neel, K. Amouriaux, JC Martin, M. Rimbert, A. Besançon, S. Giraudet, C. Terrien, M. Aliaga, N. Salabert-Le Guen, C. Hémont, M. Hamidou, R. Josien
Front Immunol. 2017; 8: 102. - Download full text