PlosOne Toward a better definition of hematopoietic progenitors suitable for B cell differentiation

Florian Dubois1, Anne Gaignerie2, Léa Flippe1, Jean-Marie Heslan1,2, Laurent Tesson1, Mélanie Chesneau1, Fabienne Haspot1, Sophie Conchon1, Laurent David1,2,
Sophie Brouard1
1 Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France
2 Université de Nantes, CHU Nantes, Inserm, CNRS, SFR Santé, FED 4203, Inserm UMS 016, CNRS UMS 3556, Nantes, France

Dubois et al., PLoS One 2020

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PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy

Sylvain Simon1,2,3, Valentin Voillet3, Virginie Vignard1,2,4, Zhong Wu5, Camille Dabrowski6, Nicolas Jouand2,7, Tiffany Beauvais1,2,4, Amir Khammari1,6, Cécile Braudeau8,9, Régis Josien9, Olivier Adotevi10,11, Caroline Laheurte10,11, François Aubin12, Charles Nardin12, Samuel Rulli5, Raphael Gottardo3, Nirasha Ramchurren13, Martin Cheever13, Steven P Fling13, Candice D Church14, Paul Nghiem14, Brigitte Dreno1,6, Stanley R Riddell15 and Nathalie Labarriere1,2
1. Inserm UMR1232, CRCINA, Nantes, Pays de la Loire, France / 2. LabEx IGO “Immunotherapy, Graft, Oncology”, Nantes, France / 3. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA / 4. CHU of Nantes, Nantes, France / 5. Qiagen Sciences, Frederick, Maryland, USA / 6. Dermatology Unit, CHU Nantes, Nantes, France / 7. Platform Cytocell, SFR Santé Francois Bonamy, Nantes, France / 8. CHU Nantes, Laboratoire d'Immunologie, Nantes, France / 9. CRTI, INSERM, Université de Nantes, Nantes, France / 10. INSERM UMR 1098, Besançon, France / 11. CHU de BESANCON, Besancon, France / 12. Dermatology Unit, Besancon Hospital, Besançon, France / 13. Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA / 14. Dermatology, Division of Dermatology, Department of Medicine, UW School of Medicine, Seattle, Washington, USA / 15. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Journal for ImmunoTherapy of Cancer (Vol 8, Issue 2 - October 25th, 2020) - Download full text
Beyond CAR T cells: Engineered Vγ9Vδ2 T cells to fight solid tumors

Chirine Rafia1,2,3, Christelle Harly1,2, Emmanuel Scotet1,2
1 INSERM, CNRS, CRCINA, Université de Nantes, France
2 LabEx IGO “Immunotherapy, Graft, Oncology”, Nantes, France
3 ImCheck Therapeutics, Marseille, France

Immunological reviews, Sept 2020. C. Rafia, C.Harly, E.Scotet

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Combined chemotherapy and allogeneic human Vγ9Vδ2 T lymphocyte immunotherapies efficiently control the development of human epithelial ovarian cancer cells in vivo

Noémie Joallanda,b, Laura Lafrancea,b, Thibauld Oullierc, Séverine Marionneau-Lambotc, Delphine Loussouarna,d, Ulrich Jarrya,b*, and Emmanuel Scoteta,b*
a CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes, Nantes, France;
b LabEx IGO “Immunotherapy, Graft, Oncology”, Nantes, France;
c Cancéropôle du Grand Ouest, Plateforme In Vivo, Nantes, France; dCentre Hospitalier-Universitaire (CHU) de Nantes, Nantes, France

ONCOIMMUNOLOGY 2019, VOL. 8, NO. 11, N. Joalland et al.
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Emerging Challenges of Preclinical Models of Anti-tumor Immunotherapeutic Strategies Utilizing Vg9Vd2 T Cells

Noémie Joalland1,2 and Emmanuel Scotet1,2*
1 Université de Nantes, INSERM, CNRS, CRCINA, Nantes, France
2 LabEx IGO “Immunotherapy, Graft, Oncology”, Nantes, France

Front. Immunol., 22 May 2020  N. Joalland et al.

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Transcriptional meta-analysis of regulatory B cells

Florian Dubois1,2 , Sophie Limou1,3, Mélanie Chesneau1,2, Nicolas Degauque1,2, Sophie Brouard1,2,4 and Richard Danger1,2
1. Inserm, CHU Nantes, Université de Nantes, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France
2. Labex IGO, Nantes, France
3. Ecole Centrale de Nantes, Computer Sciences and Mathematics department, Nantes, France
4. Centre d’Investigation Clinique en Biothérapie, Centre de ressources biologiques (CRB), Nantes, France

Eur. J. Immunol. June 2020. F. Dubois et al.

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Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials


Birgit Sawitzki, Paul N Harden, Petra Reinke, Aurélie Moreau, James A Hutchinson, David S Game, Qizhi Tang, Eva C Guinan, Manuela Battaglia, William J Burlingham, Ian S D Roberts, Mathias Streitz, Régis Josien, Carsten A Böger, Cristiano Scottà, James F Markmann, Joanna L Hester, Karsten Juerchott, Cecile Braudeau, Ben James, Laura Contreras-Ruiz, Jeroen B van der Net, Tobias Bergler, Rossana Caldara, William Petchey, Matthias Edinger, Nathalie Dupas, Michael Kapinsky, Ingrid Mutzbauer, Natalie M Otto, Robert Öllinger, Maria P Hernandez-Fuentes, Fadi Issa, Norbert Ahrens, Christoph Meyenberg, Sandra Karitzky, Ulrich Kunzendorf, Stuart J Knechtle, Josep Grinyó, Peter J Morris, Leslie Brent, Andrew Bushell, Laurence A Turka, Jeffrey A Bluestone, Robert I Lechler, Hans J Schlitt, Maria C Cuturi, Stephan Schlickeiser, Peter J Friend, Tewfik Miloud, Alexander Scheffold, Antonio Secchi, Kerry Crisalli, Sang-Mo Kang, Rachel Hilton, Bernhard Banas, Gilles Blancho, Hans-Dieter Volk, Giovanna Lombardi, Kathryn J Wood, Edward K Geissler

The Lancet, Volume 395, Issue 10237, 23–29 May 2020, Pages 1627-1639

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Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes

Lucine Marotte, Sylvain Simon, Virginie Vignard, Emilie Dupre, Malika Gantier, Jonathan Cruard, Jean-BaptisteAlberge, Melanie Hussong, Cecile Deleine, Jean-MarieHeslan, Jonathan Shaffer, Tiffany Beauvais, Joelle Gaschet, Emmanuel Scotet, Delphine Fradin, Anne Jarry, Tuan Nguyen, Nathalie Labarriere

Journal for ImmunoTherapy of Cancer (January 29,2020) - Download full text